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We then carried out metagenomic Evaluation on the identical samples to find the existence of reads from pks+ genes. As proven in Fig. three, the pks+ genes could be detected during the sequencing knowledge through the samples (both cancers or normal) in 19 individuals from thirty, Hence validating the presence on the mutational and indel signatures (see also Supplementary Figs. six and 7). Notably, While the existence of pks+ genes during the sample indicates the presence on the genotoxic E. coli strands, the mutational signature is the result of typically past exposure, for this reason it could be accrued in cell genomes previously with out pks+ getting current in the intervening time of sampling.
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Tissue distribution Mainly found in colorectal cancers, and regular and inflammatory bowel disease-afflicted colorectal epithelial cells, as well as in a few samples derived from head and neck most cancers, urinary tract most cancers and oral squamous cell carcinoma.
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